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Parallel chemistry has become an essential tool in modern drug discovery, allowing for the rapid and efficient synthesis and optimization of large compound libraries. This technique significantly accelerates the process of identifying and optimizing lead compounds, providing medicinal chemists with the ability to explore chemical space more thoroughly and efficiently.
Our parallel synthesis platforms and the diversity of chemistries we employ deliver an exceptionally high success rate demonstrating that there is no longer a direct correlation between the number of chemists (FTEs) and the number of molecules produced. This defies traditional market standards that a medchem project requires a large number of chemists in a low-cost CRO. At SpiroChem, we focus on delivering the exact number of molecules needed, ensuring high-quality design and synthesis.
1. Library synthesis - parallel synthesis enables the rapid generation of large and diverse compound libraries, crucial for initial hit identification and subsequent lead optimization. We can perform parallel synthesis in both 24/96-well plate formats in solution or on hundreds of molecules on solid phase.
2. High-throughput experimentation - simultaneous testing of multiple parameters using the same general conditions—invaluable for optimizing reactions and enabling rapid screening of reaction conditions to identify the most effective parameters for synthesis.
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