Advanced Chemistry Technology

The most advanced chemistry technology platforms on the market

Technology

Innovation underpinned by a collective knowledge base and advanced technology platforms.

We combine state-of-the-art techniques with deep expertise to deliver solutions that meet the highest standards of quality and efficiency. Our commitment to excellence ensures that we remain at the forefront of innovation in the life sciences, addressing complex chemistry challenges and advancing the path to new therapeutics.

Our extensive investment in platforms such as parallel chemistry and high-throughput experimentation (HTE) enables us to serve a wide range of projects, from the most challenging synthetic routes to high productivity demands for projects of lesser complexity.

We pride ourselves on our exceptionally high success rate, leveraging our advanced technology platforms and world-class and dynamic team. Additionally, we have developed expertise in niche chemical classes that are emerging modalities requiring our ability to handle complexity, pioneering what can be synthesized and tested.

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Allowing you to advance your research program

Our team and platforms offer a scalable capacity that can flex to your requirements.

Computational Chemistry

AI/ML-ready data, automation and parallelization

New Modalities

Specialty Techniques

SpiroChem leverages advanced chemistry technology platforms for innovative solutions in drug discovery and development.

Rapidly advance your research with our world-class chemistry expertise and advanced technology platforms.

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Success Story / MedChem

Who: Biotech

Where: Asia

Problem: Design, synthesis and optimization of novel bicyclo[x.y.z]alkane derivatives

SpiroChem assigned one chemist of FTE-based contact for 6 months:

4 series developed: 20 final molecules delivered (5 to 15 steps)
New methodology developed for the synthesis of bicyclo[x.y.z]-pyrazole derivatives by modification of key functionalities
Successful introduction of 10 new bicyclo[x.y.z]alkane derivatives for use as non-classical bioisosteres
Validation of bioisosteric switch concept
Generation of novel chemical space
3D design confirmed by X-ray crystallography
Subnanomolar activity and excellent ADME profile achieved

Our technology

01 Computational chemistry

Our computational chemistry expertise is seamlessly integrated within our multidisciplinary team, enabling us to deliver optimal results efficiently. Whether as a stand-alone service or as part of a larger project, our computational chemistry support is designed to accelerate your path to success.

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02 AI/ML-ready data

We recognize the critical importance of high-quality, machine-readable data to support AI/ML applications in chemistry and have made significant strides in developing our own algorithmic ecosystem designed to augment the capabilities of our scientists, creating an "augmented chemist" capable of making faster and more informed decisions.

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03 New modalities

SpiroChem offers expertise and innovative solutions across various new modalities. These innovative approaches encompass a diverse range of therapeutic strategies, including protein degraders, antibody-drug conjugates (ADCs), bioconjugates, macrocycles, covalent inhibitors, and oligonucleotide-based therapeutics (OLNs).

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04 Specialty techniques

SpiroChem is pioneering specialty techniques, providing expertise and cutting-edge solutions that enhance the drug discovery and development process. Our team of world-class scientists utilize photochemistry, flow chemistry solid phase synthesis, parallel synthesis platforms and high-throughput experimentation, linker design, analytical and preparative electrochemistry, and lipids and drug delivery to deliver high-quality results.

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What our clients
say about us

As a reliable partner with a world-class team of chemistry experts, SpiroChem delivers high-quality solutions offering you the ‘best chance of being successful’

Testimonials

“Our collaboration with SpiroChem has enhanced our ability to investigate novel chemical space. The SpiroChem team and our team have built an outstanding partnership, working closely to resolve tough synthetic issues and quickly explore areas, which - without their expertise - would have been challenging. Their emphasis on communication, rapid delivery with uncompromised quality and troubleshooting solutions makes SpiroChem a highly recommended partner.”