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Macrocycles in drug discovery: a bRo5 compound class re-discovered
Covering a new chemical space with atom-economical synthesis and functionalization of sp3-rich scaffolds
Route Scouting at SpiroChem: bridging between MedChem and API manufacture
No Strain, No Gain: Advances in the Synthesis and Design of New Classes of Strained Building Blocks
Pharmacophore-based Virtual Screening: Examples Using The New SpiroChem Libraries
The kinase-phosphatase mystery: a prolific and an underexplored target family
Targeting Protein Kinases with Covalent Inhibitors
Pushing boundaries: Photoinduced Assembly of C-N and C-C bonds
Pushing boundaries: New methodologies and enabling technologies to decorrelate structural complexity from synthetic accessibility
Pushing boundaries: Design of highly 3D libraries and case studies
Pushing boundaries: Break-it-to-Make-it Strategies for Chemical Synthesis Inspired by Complex Natural Products
Reshaping Flatland: Dearomative Methods for Rapid Construction of Valuable 3D Molecules
Reshaping Flatland: the story behind small rings and spirocycles
Reshaping Flatland: Methods to access novel 3D conformationally-restricted motifs: it’s all about efficiency
Reshaping Flatland: The principles of constraining lipophilicity, saturation and shape
