Macrocycle Library

Advancing your research program by delivering the world’s best chemistry

Macrocycle Library

Collection of 8000+ macrocycles

Our SpiroQUEST™ Library has been carefully designed to include many chemotypes while providing a usefully diverse range of parameters. SpiroChem also offers library design services complementing its current macrocycle compound collection and leveraging its macrocycle expertise for your needs.

Enrich your screening decks with enabled beyond the ‘Rule of Five’ starting points

Macrocycles are privileged structures in medicinal chemistry as they successfully expand the available compound space and have special features that make them druggable despite being beyond the ‘Rule of Five’.

About Macrocycles

Macrocycles are privileged structures in medicinal chemistry as they:

Provide diverse functionality and stereochemical complexity in a conformationally pre-organized ring structure
Are semi-rigid compounds, a compromise between structural pre-organization (entropy) and sufficient flexibility to mold to a target surface and maximize binding (induced fit)
Can demonstrate drug-like physicochemical and good pharmacokinetic properties such as solubility, lipophilicity, metabolic stability, cell (and blood-brain barrier) permeability and bioavailability beyond the ‘Rule of Five’

Advancing your research program by delivering the world’s best chemistry. Collection of 8000+ macrocycles. Discover more!

Well-balanced properties

The SpiroQUEST™ Library was developed over several years to maximize chemical and topological diversity. The macrocycles (12-30 atoms) incorporate naturally occurring and non-natural amino acids as well as 1600+ non-peptidic linkers to vary ring size/nature, add heteroatoms, pharmacophores, and introduce conformational constraints.

Let’s work together

The apparent complexity of the structures is decorrelated from their synthetic accessibility. The chemical space surrounding the SpiroQUEST™ Library is fully enabled thanks to our proprietary platform: We guarantee a rapid turn-around time for hit validation and downstream optimization work.

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Step 1: Purchase of SpiroQUEST™ Library
Format
- Available as 10 mM DMSO solution
- Standard volumes: 2 or 5 µL
- Plate format: Greiner 784201
- Other plate format available on request
Step 2: Screening of the SpiroQUEST™ Library
Screening
- Performed by partner, or third-party screening center
- Note: SpiroChem has screening partners and can arrange/coordinate screening efforts.
Step 3: Hit Analysis and Validation
Workflow
- Hit analysis by SpiroChem
- Preparation of a validation library of 48-96 analogues around selected hits
- Unblinding* of hits
- Resynthesis of hits and supply
Step 4: Hit-to-Lead and Lead Optimization
Workflow
- Hit-to-lead and lead optimization
Contact us to discuss your research

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What our clients
say about us

As a reliable partner with a wealth of experience, SpiroChem offers clients unparalleled quality solutions supported by a world-class and dynamic team of chemists.

Testimonials

“Odyssey Therapeutics and SpiroChem collaborated on the synthesis of complex molecules and chemical libraries. The SpiroChem team was highly engaged as we defined the scope and aims of the work. SpiroChem worked quickly to evaluate multiple chemistries in parallel. Together, we defined the most productive and impactful path forward, executing on state-of-the-art, challenging synthetic transformations then quickly converting the results to library production. Our collaboration proceeded smoothly as SpiroChem scientists were model collaborators who communicated promptly, provided very efficient logistics, and exhibited a true can-do spirit. It was a pleasure to work with the SpiroChem team and we look forward to future work together.”