SpiroKits™

The must-have medical chemistry toolboxes

Our organic and medicinal chemists have designed a panel of SpiroKits, made from a selection of high added-value molecules, to meet specific chemistry issues, foster chemical space exploration and support novelty.

At SpiroChem, our structurally complex compounds can enhance existing molecules and portfolios, or even help you develop a new and rich portfolio of novel, patentable molecules.

Get in touch

Select your SpiroKit

01 pKa-Tuned Amines

SpiroKit 1 is a smart selection of 66 amines with modulated pKa to help medicinal chemists consider the full potential of the basic centers carefully.

SpiroKits™ enable you to get your portfolio to market faster. The must-have medical chemistry toolboxes. Learn more!

02 sp2 to sp3 switch

SpiroKit 2 is a smart selection of 33 sp3 building blocks to encourage medicinal chemists to switch from sp2 systems to conformationally restricted sp3 systems, to get access to compounds with outstanding intrinsic properties.

03 Constrained N-Boc amino acids

SpiroKit 3 is a smart selection of 49 constrained N-Boc amino acids which are fundamental building blocks of modern chemistry. The combination of readily functionalized amine and carboxylic groups attached to a chiral center along with a conformationally restricted side chain provides innovative three-dimensional structures with a high degree of functionality.

04 Azaspiro[3.3]heptane derivatives

SpiroKit 4 is a smart selection of 30 azaspiro[3.3]heptane derivatives which are viable and promising surrogates for the piperidine, piperazine, morpholine and thiomorpholine rings, commonly used building blocks in medicinal chemistry.

05 Bicyclic diamines

SpiroKit 5 is a smart selection of 41 monoBoc bicyclic diamines, valuable analogs and surrogates of piperazine which is one of the most used building blocks in medicinal chemistry.

06 Constrained amino alcohols

SpiroKit 6 is a smart set of 53 constrained secondary and tertiary amino alcohols.

07 Bicyclic amino ketones

SpiroKit 7 is a smart selection of 32 bicyclic amino ketones, valuable structurally diverse precursors of amino piperidine surrogates.

08 Constrained N-Fmoc amino acids

SpiroKit 8 is a smart selection of 26 original constrained N-Fmoc amino acids. A high degree of functionality and 3D shapes are readily available through the combination of functionalized amines and carboxyl groups linked to a conformationally restricted side chain.

Diversify your medicinal chemistry toolbox

Get in touch

What our clients
say about us

SpiroChem is unparalleled in its offering with a world-class team of chemists providing high-quality solutions. We are a reliable partner with a wealth of experience.

Testimonials

“SpiroChem is a reliable partner for our lead optimization programs. We have been working with SpiroChem for several years in a fruitful and trustworthy relationship. The SpiroChem team - based on strong knowledge of synthetic and medicinal chemistry – always performs effectively to boost our structure-activity relationship studies. And when it comes to the synthesis of challenging targets, SpiroChem also solved many synthetic issues with unique and sophisticated ideas that no other CRO can provide. It stimulates us and brings great results and value to our projects. For this reason, SpiroChem is a highly recommended partner for discovery.”