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Bioisosteric replacement is a useful tool for altering the pharmacokinetics or toxicity of a lead compound, by generating new molecules with similar biological properties to the parent compound, but different physical-chemical properties and favorable ADME properties. These strategies can be physicochemically or topologically based. SpiroChem has established itself as a world-leading expert on bioisosteric switch strategies.
We are constantly proposing new hypotheses and developing new concepts to help medicinal chemists improve their lead candidates—expanding into new IP-free chemical spaces.
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