SAR Elucidation

Addressing your specific needs as a best-in-class chemistry contract research organization

Understanding structure-activity relationships (SAR) is critical in drug discovery.

The initial aspect of SAR involves determining whether such a relationship exists in a collection of molecules and their associated activities.

Once found, elucidating SAR can provide invaluable information that allows chemists to make structural modifications to a compound to optimize its activity or properties.

Understanding structure-activity relationships (SAR) is critical in drug discovery. Learn more!

SpiroChem can also optimize properties through photoredox catalysis, using late-stage functionalization with small groups, to adjust properties such as potency, selectivity, or pharmacokinetic profile of an advanced lead.

We employ SAR studies, molecular modeling, and synthetic chemistry strategies to iteratively modify hit chemical structure.

The goal is to maintain the desired biological activity while addressing issues related to toxicity, solubility, and metabolic stability.

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With a wealth of experience in chemistry, SpiroChem offers clients unparalleled high-quality solutions supported by a world-class team of experts.

Testimonials

“SpiroChem services have been invaluable with lead optimization, starting with medicinal chemistry advice, following with compound synthesis, and finally reporting. We now have a more comprehensive understanding of the structure-activity relationship and a more solid foundation for our IP. The SpiroChem team are very efficient and deliver excellent quality on time, providing good value for money.”