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Choosing the wrong chemical route wastes time, money, and effort, and often fails at scale. Our route scouting approach removes uncertainty, enabling the selection of robust and scalable synthetic strategies to keep development on track.
Route scouting involves the strategic identification and evaluation of efficient and scalable synthetic routes. This approach is tailored to the specific requirements of the target compound. Leveraging our expertise in chemical process development, deep organic chemistry knowledge, and incorporating insights from our clients, we evaluate a range of feasible strategies to rapidly prioritize and advance the most promising options.
Alternative routes are designed and prioritized based on their potential for scale-up, considering projected cost of goods, scalability, and development feasibility. SpiroChem’s route scouting efforts also encompass the exploration of novel synthetic methodologies and the use of advanced modern technologies to enable innovative disconnections and meet sustainability criteria that are often difficult to achieve with more traditional chemistry.
After disclosure of the target molecule by the client, our approach consists in:
A demo batch is usually performed on a 10’s to 100’s g scale to test the robustness of the novel synthesis. A tech transfer package will then be prepared, with SpiroChem supporting the transition to customer’s CDMO of choice.
This is a story about how SpiroChem rescued a failed tech transfer from near disaster and turned it into a success. A story about a promising molecule’s path to phase 1 clinical trials, jeopardized by an unoptimized synthetic route.
When a Swiss biotech contacted SpiroChem, they were at a critical point. Their tech transfer to their CDMO of choice failed during the 5th step (out of 6), leaving them with kilograms of unusable crude reaction mixture.
In just three months, SpiroChem redesigned the process into a 2-step synthesis, introducing stereocenters last via C-H activation. Then successfully delivered 200g of compound for toxicology studies, followed by a seamless tech transfer to a Swiss CDMO.
At SpiroChem, we leverage advanced molecular design and route-scouting technologies to help biotech and pharmaceutical teams overcome synthesis and scale-up bottlenecks. Complex spirocyclic building blocks shouldn’t stand in the way of a Phase III program—but for one U.S.-based biotech company developing an oncology candidate, that was exactly the challenge.
Customer’s route faced:
Our Approach:
SpiroChem partnered with the biotech team to rethink the chemistry from the ground up. In just six months, we delivered a fully redesigned synthetic route that:
This collaborative network ensures that each HTE campaign can leverage the best available catalysts and technologies, accelerating optimization and increasing the rate of success.
The Results:
