Early ADME And Physical-Chemistry Properties

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Early ADME and physical-chemistry properties

Absorption, distribution, metabolism and excretion (ADME) are processes that can distinguish “good” drug candidates.

To avoid high attrition rates at the hit-to-lead stage, early assessment of physical-chemical properties of hits can be of critical importance. At SpiroChem, we have the experience and the expertise to perform early ADME assays, providing you with the most promising targets. Key ADME experiments include early physicochemical profiling, permeability and clearance measurements and cytochrome P450 (CYP) inhibition.

We have the expertise to perform early ADME assays, providing you with the most promising targets. Learn more!

With a range of computational and chemical tools such as our Pion Sirius T3 platform, we have the capabilities for assessing and measuring these key physical-chemical parameters - considering the ‘Rule of Three’ for fragments and ‘Rule of Five’ for lead compounds. We are also well versed in the assessment of properties of ’beyond Rule of Five’ compounds.

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With a wealth of experience, SpiroChem offers unparalleled high-quality solutions supported by a world-class team of chemists.

Testimonials

“SpiroChem has been our very effective partner in drug development. They showed outstanding performance even with demanding syntheses of compounds and they delivered what they promised on time. Their professionalism was obvious in every step, from targeted synthesis design to implementation and report. The SpiroChem team combines creativity and commitment, as well as efficient problem-solving capability, that are keys to the success of the project. Smooth communication facilitated our productive collaboration. I would highly recommend SpiroChem.”