Hit Validation

Tackling complex challenges at the most critical steps in drug discovery

Hit validation is crucial in rigorously confirming and prioritizing promising candidates for further optimization.

Hit validation is essential for eliminating false positives from high-throughput screens, demonstrating that a hit has the potential to bind to a target of interest - with no obvious chemical features that would make it difficult to develop into a drug.

SpiroChem’s libraries provide high quality molecules with well-balanced physical-chemical properties and chemical tractability, ensuring that the identified hits are amenable to further medicinal chemistry efforts.

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As a reliable partner with a wealth of experience, SpiroChem offers clients unparalleled high-quality solutions supported by a world-class and dynamic team of chemists.

Testimonials

“SpiroChem is a reliable partner for our lead optimization programs. We have been working with SpiroChem for several years in a fruitful and trustworthy relationship. The SpiroChem team - based on strong knowledge of synthetic and medicinal chemistry – always performs effectively to boost our structure-activity relationship studies. And when it comes to the synthesis of challenging targets, SpiroChem also solved many synthetic issues with unique and sophisticated ideas that no other CRO can provide. It stimulates us and brings great results and value to our projects. For this reason, SpiroChem is a highly recommended partner for discovery.”