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As a chemistry contract research organization (CRO) we offer a wide range of services spanning medicinal chemistry, proprietary compound collections, computational chemistry, and early absorption, distribution, metabolism and excretion (ADME) and PhysChem properties.
SpiroChem has a world-class and dynamic team of hand-picked experts covering all aspects of chemistry and led by seasoned scientific leaders. Our innovative approach to problem-solving enables clients to be agile in their discovery processes.
Our dedicated experts work as an extension of your team, bringing enthusiasm, creativity, and competency to every challenge, also leveraging SpiroChem’s collective know-how, the SpiroBrain. We offer you the ‘best chance of being successful’ that significantly derisks your research programs.
Our deep, collective knowledge base in drug discovery extends beyond our facilities, giving you access to SpiroChem’s network of high-quality trusted research partners, all orchestrated by SpiroChem to give you peace of mind. We guide your project from hit validation to lead optimization in fully-integrated medicinal chemistry projects.
In the intricate landscape of drug discovery, SpiroChem thoughtfully orchestrates chemical pathways tailored to your needs. Being at the confluence of innovative chemistry and the most advanced technologies on the market means we can deliver comprehensive and interpretable data, using a broad range of analytical platforms.
Our high-throughput chemistry expertise allows quick design and synthesis of novel hit expansion libraries, thereby shortening design-make-test (DMT) cycles and accelerating the decision process at each iteration. With refined computational techniques and a comprehensive understanding of medicinal chemistry, we produce high-quality and diverse leads for optimization.
Through a network of partners and trusted CROs, we optimize molecules on ADME/PK parameters (early absorption, distribution, metabolism, excretion, and toxicity profiling, pharmacokinetic/pharmacodynamic (PK/PD) correlations.
Once a development candidate is selected, tech transfer to other CROs and to CDMOs is facilitated by our detailed experimental protocols and reports, describing with precision what was successful and what was not, as well as suggestions for future work. We remain available for consulting and troubleshooting.
SpiroChem provides medicinal chemistry services in addition to fully integrated, comprehensive drug discovery services through our network of high-quality trusted partners in biophysics, biology, and pharmacology.
We have experts in all fields of drug design, and we can support you with our FTE-based services, offering full medicinal chemistry programs or support for a specific phase of your project.
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SpiroChem has thoughtfully curated its database of chemical compounds, making it easier for you to select the product best suited for your project and scale.
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Our computational chemistry expertise is seamlessly integrated within our multidisciplinary team, ensuring the security and confidentiality of your data. We use a commercial suite of modelling programs complemented by state-of-the-art open-source programs, pipelining tools, and databases. This combination empowers us with great flexibility, allowing us to maximize our effectiveness and offer a diverse range of solutions to meet your specific needs.
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SpiroChem has the experience and expertise to perform ADME assays, providing you with the most promising targets. Key ADME experiments that can be performed at SpiroChem or with our partners include early physicochemical evaluation, permeability and clearance measurements and cytochrome P450 (CYP) inhibition. More advanced ADME are routinely performed with trusted vendors.
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