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Molecular scaffolds are an opportunity to charter new chemical and property spaces. SpiroChem offers a range of compact scaffolds that allow for multiple exit vectors to explore a virtually infinite number of dihedral angle combinations.
Our ongoing internal R&D programs continuously develop novel scaffolds based on a deep, collective knowledge base – our ‘SpiroBrain’ - and the most advanced technology platforms on the market.
Spirocycles are 3D scaffolds and very useful for scaffold-hopping strategies. Many of our scaffolds bring an extra degree of rigidity that can be useful to reduce entropy. Classical scaffolds bearing exit vectors can be replaced by spirocyclic cores and it is possible to fine-tune their geometrical properties to access almost any possible set of dihedral angles and distance between each exit vector.
Spirocycles together with other classes of bicycles are very powerful tools for chemical space expansion. Our compact scaffolds allow for multiple exit vectors to explore a virtually infinite number of dihedral angle combinations. Furthermore, these scaffolds have also been included in several DNA-encoded libraries.
Harnessing our deep, collective knowledge base, we can assist you in the design and synthesis of analogs to fully explore and exploit the potential of our scaffolds.
We can bring your portfolio to market faster.
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