Covalent Inhibitors

Creating strong ties

Covalent Inhibitors

Covalent inhibitors form a permanent bond with their target proteins, offering a unique mechanism of action that can lead to prolonged therapeutic effects. Once an undesirable effect with believed adverse effects, it has now become a mainstream approach to target “undruggable” proteins.

At SpiroChem, we specialize in the design and synthesis of covalent inhibitors, providing our clients with the tools needed to develop these powerful therapeutics. Our team is skilled in identifying suitable covalent warheads and designing selective inhibitors that optimize pharmacological properties.

We support clients through every stage of development, from initial concept to preclinical testing, ensuring that their covalent inhibitors are both effective and safe. Our expertise enables us to create inhibitors that offer prolonged and targeted therapeutic effects.

We specialize in the synthesis of covalent inhibitors, providing our clients with the tools needed to develop these powerful therapeutics.

Our expertise

We leverage our deep understanding of protein-ligand interactions and advanced synthetic methodologies to deliver covalent inhibitors that address challenging therapeutic targets.

Our collaborative approach ensures that each project benefits from our collective expertise, driving innovation and success in the development of covalent inhibitors.

Our services in covalent inhibitor development include:

Identification and optimization of covalent warheads
Design and synthesis of selective covalent inhibitors
Comprehensive support from initial concept to preclinical testing
Integration of computational chemistry for structure-based design
Utilization of our proprietary library of covalent fragments to generate hits (this service can also be offered as a fully integrated package with our biology screening partners)
Development of residue-specific warheads targeting not only cysteine but also other residues such as lysine, tyrosine, and more

By integrating our expertise in covalent inhibitor design with state-of-the-art facilities and analytical tools, we ensure that our clients receive high-quality support and innovative solutions. Our commitment to excellence accelerates the development of effective and safe covalent inhibitors, addressing unmet medical needs and advancing therapeutic development.

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What our clients
say about us

As a reliable partner with a world-class team of chemistry experts, SpiroChem delivers high-quality solutions offering you the ‘best chance of being successful’

Testimonials

“Thank you SpiroChem for your work, it was a truly exciting and fruitful collaboration. You did an outstanding job in an extremely short period of time. We really appreciated the regular reports of your progresses and the dynamic exchanges we had on these occasions, in a nice yet very professional atmosphere. Overall, we believe that our work with SpiroChem was a success and have significantly contributed to move forward with our project.