Properties Optimization

Optimizing existing portfolios with the most advanced technology platforms on the market

Properties optimization

Enhancing ADME properties for less off-target toxicity, better therapeutic efficacy, and competitive dosing.

SpiroChem can support properties optimization by utilizing computational methods and algorithms through computer-aided drug design to facilitate the rational design of novel therapeutic compounds with specific interactions and desired properties.

With a wealth of experience, we offer clients unparalleled solutions supported by a world-class team of chemistry experts.

We fully incorporate our knowledge in bioisosterism to systematically screen new hits which maintain potency while improving absorption, distribution, metabolism and excretion (ADME) properties, providing new chemical matter and ensuring freedom to operate.

SpiroChem can also optimize properties through photoredox catalysis, using late-stage functionalization with small groups, to adjust properties such as potency, selectivity, or pharmacokinetic profile of an advanced lead.

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What our clients
say about us

As a reliable partner with a wealth of experience, SpiroChem offers clients unparalleled high-quality solutions supported by a world-class team of chemistry experts.

Testimonials

“SpiroChem has been our very effective partner in drug development. They showed outstanding performance even with demanding syntheses of compounds and they delivered what they promised on time. Their professionalism was obvious in every step, from targeted synthesis design to implementation and report. The SpiroChem team combines creativity and commitment, as well as efficient problem-solving capability, that are keys to the success of the project. Smooth communication facilitated our productive collaboration. I would highly recommend SpiroChem.”