Expertise of the month: Synthetic shortcuts to access uncharted chemical space fast!

On top of having strong know-how to synthesize novel sp³-rich fragments, SpiroChem is constantly developing novel strategies to accelerate discovery by shortening synthetic routes.

Thanks to modern disconnection consideration and smart use of enabling technologies such as photochemistry and electrochemistry, SpiroChem enlarges the fragment’s sociability space dramatically and gives access to growth vectors that would be tricky to consider by classic chemistry.

Late-stage functionalization is also a very powerful strategy in the case of covalent fragments enabling, for example, the introduction of covalent warheads on spirocyclic sp²-sp³ fragments by innate C-H functionalization.

You will find more information in our recent publication DOI: 10.1039/d3ob01746j