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SpiroTeam

Feb 19, 2021

SpiroChem strengthens its Advisory Team and welcomes...

Newsletter

Feb 19, 2021

SpiroKit 4: Azaspiro[3.3]Heptane Derivatives

Press Releases

Feb 12, 2021

SpiroChem sponsors two postdocs and one PhD...

SpiroTeam

Feb 05, 2021

SpiroChem strengthens its Advisory Team and welcomes...

Expertise of the month

Jan 29, 2021

Expertise of the month: Nucleoside/Nucleotide Chemistry

Press Releases

Dec 01, 2020

Exploration of linker and bioisostere technology and...

Expertise of the month

Nov 27, 2020

Expertise of the month: State-of-the art technologies...

COVID-19 Statement

Nov 19, 2020

COVID-19: SpiroChem remains fully operational amidst global...

Literature

Oct 30, 2020

Pushing the Frontiers of Accessible Chemical Space...

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Discovery
Process R&D
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Get in touch

contact@spirochem.com +41 61 685 9500 Follow us

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Stay Connected

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Medicinal Chemistry

Our Mission: Accelerate your project!

Typically : 1-6 chemists

Duration : 3-12+ months

Excellence in chemistry
Creative drug design
Solution and productivity driven
Uncompromised quality

Full MedChem programs or Support for a specific phase:

Hit Validation
Hit/Fragment Expansion
Hit-to-Lead

Lead Optimization
SAR Elucidation
Bioisosteric replacement strategies

Properties Optimization
Back-up programs
IP Evaluation
Patent Filing

Hit Validation
Hit/Fragment Expansion
Hit-to-Lead
Lead Optimization
SAR Elucidation

Bioisosteric replacement strategies
Properties Optimization
Back-up programs
IP Evaluation
Patent Filing

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MedChem Enabling Platforms

Our Mission: Explore new chemical space for you

Typically : 2-5 chemists

Duration : 3-12+ months

Opening of new exit vectors
Late-stage functionalization
Synthesis tractability
Unleashed design

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Fragment Libraries

Our Mission: Address unexplored chemical space and diversity

+700 molecules in stock
Unique design
High sp³ content
Conformationally restricted structures
Scale-up and straightforward analoging guaranteed

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DEL Scaffolds

Our Mission : Offer exclusive scaffolds

Bi- and tri-functionalized scaffolds
Uncharted chemical space
Unique dihedral angles covered
Orthogonal protecting groups
Vectors : COOH, CHO, Aryl halides, Nboc, Nfmoc, boronates

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Route Scouting

Our Mission: Design and implement de novo synthetic routes

Typically: 1-3 chemists

Duration: 3-6+ months

De novo design of synthetic routes to target molecules
Trouble-shooting
Development of efficient in-process controls
Stress test, robustness check
Technology transfer package

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SpiroKits

The must-have medicinal chemistry toolbox designed to:

Provide medchem turnkey solutions
Accelerate projects
Foster chemical space exploration
Support novelty

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Catalog

Our mission: Accelerate your R&D

+13 000 molecules
Innovative building blocks
Purity > 95%
Milligram to hundred gram scale
Short delivery time

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Consulting

Our mission: Share our knowledge

Literature analysis
Analysis of SAR results and proposals
Strategy proposals for ADME optimization
Retrosynthetic analysis
Route scouting proposals
Patent gap analysis
Support for patent filing

*hourly rate, daily rate or project-based fee

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Computational Chemistry

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