We are pleased to announce that one of our recent papers, published in Q4 2022, has been ranked in the top 25 most-read articles in Nature Communications. The article, titled "-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes", was published in October 2022 and has received a great deal of attention in the scientific community. This work is the result of a fruitful collaboration between SpiroChem, Novartis and the group of Prof. M. Kevin Brown at Department of Chemistry at Indiana University.
The impact of this article shows how important and useful our strategy to establish collaborations with academia is, and we are incredibly proud of the teams for their hard work and dedication.
The paper describes the development of ladderanes as a new class of isosteres for meta-substituted aromatic rings and has important implications for the design of new drugs. We believe that the research will continue to spark important conversations and advance our understanding of the development of novel bicyclic building blocks to enable medicinal chemistry.
Following our motto “make the molecule you should, not only the one you could” , this new class of compact modules will surely find its place in the toolbox of every medicinal chemist.
Contact us at firstname.lastname@example.org to see how you can enrich your collection and projects with this new chemotype.
Find the full article here. Enjoy reading!