SpiroChem | Where Chemistry Excellence Accelerates Discovery

Driving innovation in drug discovery and process R&D, offering expert chemistry solutions and seamless support throughout.

15 Years of Building the Discovery Engine

Scroll down

Turning hits
into candidates

SpiroChem is a pioneering research partner driving innovation across the drug discovery and process R&D chemistry value chain. With our world-class dedicated experts working seamlessly as an extension of your team, we offer the ‘best chance of being successful’ significantly derisking your research programs. Thanks to our fully integrated discovery services enabled by our high-quality trusted research partner network, we support your hit-to-candidate journey every step of the way.

Get in touch

Discovery Engine and Platforms

Discover More

High Throughput
Experimentation (HTE)

Rapidly explore reaction space and identify robust conditions through automated, data-driven experimentation.

Discover more

Hercules+™ Platform

A versatile solid-phase chemistry platform designed to accelerate complex synthesis and rapidly deliver high-quality compound libraries.

Discover more

Bead to Biology
Platform

Accelerate biological screening by combining multistep solid-phase synthesis with rapid access to diverse compound libraries.

Discover more

Fully Integrated
Services

Seamlessly connect computational chemistry, medicinal chemistry and biology through one integrated partner and trusted network.

Discover more

Computational
Chemistry

Leverage computational insight to identify novel high-value hits and guide molecular design.

Discover more

Synthetic
Chemistry

Tackle challenging molecules with deep synthetic expertise, innovative chemistry, and robust technologies built for speed and quality.

Discover more

Modalities

Discover More

Macrocycles

Unlock challenging targets combining innovative molecular design with powerful platform chemistry.

Discover more

ADCs

Develop antibody–drug conjugates through integrated expertise in payloads, linkers, conjugation chemistry, and analytical characterization.

Discover more

Drug
conjugates

Design and synthesize sophisticated drug conjugates to enable targeted delivery and explore new therapeutic opportunities.

Discover more

Peptides
& Peptidomimetics

Design and synthesize peptides and peptidomimetics to expand chemical space beyond conventional small molecules.

Discover more

Radiopharmaceuticals

Advance radiopharmaceutical discovery with innovative chemistry and molecular design for targeted therapeutic applications.

Discover more

Degraders

Accelerate the design and synthesis of protein degraders with high chemistry expertise and a linker toolbox.

Discover more

Early PR&D

Discover More

Route
Scouting

Identify efficient, robust, and scalable synthetic routes to accelerate the transition from discovery chemistry to process development.

Discover more

Demo Batches
& Scale-up

Translate promising chemistry into reproducible larger-scale batches with a focus on robustness, quality, and process readiness.

Discover more

Impurity Elucidation
& Synthesis

Isolate, elucidate, synthesize, and characterize impurities to support process development.

Discover more

What our valued clients and collaborators have to say

SpiroChem is committed to providing clients with innovative solutions. We deliver the most robust science and peace of mind to our partners, both big and small, so they can focus on advancing their research programs.

SpiroChem is a reliable partner for our lead optimization programs. We have been working with SpiroChem for several years in a fruitful and trustworthy relationship. The SpiroChem team - based on strong knowledge of synthetic and medicinal chemistry – always performs effectively to boost our structure-activity relationship studies. And when it comes to the synthesis of challenging targets, SpiroChem also solved many synthetic issues with unique and sophisticated ideas that no other CRO can provide. It is stimulating us and brings great results and value to our projects. For this reason, SpiroChem is a highly recommended partner for discovery.

Masakazu Atobe, Principal Scientist, Laboratory for Drug Discovery, Asahi Kasei Pharma

SpiroChem has played a key role in the development of Vandria. They have allowed us to make the best out of our discovery and Medicinal Chemistry project and have accompanied us all the way with route scouting for upscaling.

SpiroChem's chemists make the impossible happen, propose innovative ideas and structures, with high-quality reporting and competitive timeframe. On top of that, SpiroChem is one of the best CROs I have had the pleasure to interact with in terms of communication, reactivity, and reliability.

I can only recommend SpiroChem and look forward to continuing to work with them.

Penelope Andreux, Ph.D., Head of Drug Discovery, Vandria

As a R&D team focused on drug discovery, we've collaborated with several CROs, but SpiroChem stands out for their expertise in medicinal chemistry. Their team not only provided innovative solutions to complex synthesis challenges, but they also played a key role in the design of novel analogs that significantly advanced our research. They are very collaborative and communicative with focus on providing the best results. We highly recommend SpiroChem to any biotech in need of cutting-edge medicinal chemistry support.

Gauthier Errasti, Head of the Center for Protein Engineering and Drug Discovery

We've worked with SpiroChem for over a year on an antiviral drug discovery project. We've given them our toughest synthetic targets and they have succeeded in making them in a rapid fashion that exceeded my expectations. When faced with synthetic obstacles, they have found ways to get through or around them. They have been valuable colleagues and I would be happy to work with them again.

Peter Dosa, Research Associate Professor, Department of Medicinal Chemistry, University of Minnesota

SpiroChem has played an instrumental part in Cellestia's drug discovery and development program, proving to be a reliable partner in delivering quality results in a timely manner. Within the framework of this collaboration, the team has spared no effort in meticulously executing the plan and actively participating in project meetings to contribute to the success of our medicinal chemistry efforts. SpiroChem's innovative and effective work helped us save CHF 0,5 million on the drug development program. I thoroughly enjoyed interacting with SpiroChem's team and CEO Dr. Thomas Fessard who always made himself personally available to discuss the progress of our projects. Without any reservations, I would highly recommend SpiroChem to anyone looking for customized, innovative chemistry from a highly-invested, strikingly professional team.

Rajwinder Lehal, Chief Scientific Officer, Cellestia

In our medicinal chemistry collaboration, SpiroChem quickly learned about our project goals and used their expertise in SBDD and medicinal chemistry to suggest innovative, yet accessible targets. Following up with this initial effort, SpiroChem was able to translate those ideas into synthetic plans and generated new compounds, addressing synthetic challenges along the way. Throughout our collaboration, we enjoyed their clear and honest communication style, their flexibility, and high quality of work which, bundled together, made SpiroChem a good partner to work with.

Jean Kim, SVP Head of Chemistry, Kadmon

We partnered with SpiroChem as part of a pilot structure-based drug design and medicinal chemistry campaign. The outcome was very successful! Despite time, budget and even technical constraints, the SpiroChem team promptly addressed our difficulties providing innovative and unexplored chemical solutions. We were able to design improved compounds, better understand the chemical biology of our project, and lay the foundation for further development campaigns. The SpiroChem Chemistry team has closely supported us through the entire process providing ideas and detailed clarification of the strategies undertaken. A great partnership that I am sure to be continued!

Professor Gisou van der Goot, VP for Responsible Transformation Head of the Laboratory of Cell and Membrane Biology, EPFL

SpiroChem has been our very effective partner in drug development. They showed outstanding performance even with demanding syntheses of compounds and they delivered what they promised on time. Their professionalism was obvious in every step, from targeted synthesis design to implementation and report. The SpiroChem team combines creativity and commitment, as well as efficient problem solving capability, that are keys to the success of the project. Smooth communication facilitated our productive collaboration. I would highly recommend SpiroChem.

Thanasis Spathis, CEO of ARGO Therapeutics

SpiroChem services have been invaluable with lead optimisation, starting with medicinal chemistry advice, following with compound synthesis, and finally reporting. We now have a more comprehensive understanding of the structure-activity relationship and a more solid foundation for our IP. The SpiroChem team are very efficient and deliver excellent quality on time, providing good value for money.

Pablo German, Chief Technical Officer, Pheromite

SpiroChem is an excellent partner for several reasons. They have strong chemists who are collaborative, creative, knowledgeable, innovative, and hard working. Over the course of a one year Route Scouting project, they generated many ideas for new synthetic routes and aggressively explored each of the ideas for application to a very challenging structural motif that required a broad understanding and good command of asymmetric methodologies. In addition to generating and applying new ideas, they were also quite successful at making measurable improvements to existing synthetic processes. They are reliable and productive. All meetings went as scheduled and were always strongly supported with detailed updates covering many experiments that the project chemists could always speak to confidently and authoritatively. They are flexible and responsive. The project demanded good judgement and abrupt changes in direction at several points and the SpiroChem team was able to quickly pivot and move to higher priority activities when needed. I have no reservations in recommending SpiroChem as a partner for challenging Route Scouting projects. The SpiroChem chemists that I worked with are professional chemists who are committed to high quality science and I look forward to working with the team again on a future project.

Michael D. Wallace, Director, Process Development and Manufacturing, Assembly Bio

When only the best chemistry team will do, I turn to SpiroChem. For 10 years now, I have collaborated with chemists at SpiroChem to solve my project's most complex synthetic challenges in medicinal and process chemistry.

Denis Billen, Associate Director, Small Molecule API Chemistry, Horizon

With a complex pharmacophore to deal with and the need to devise a succinct and scalable route for development, we turned to SpiroChem for assistance. Their knowledgeable chemists made quick work of an asymmetric synthesis and notable strides in developing an optimized route. They are collaborative and communicative and will not shy away from a challenge! Given our experience to date, we would not hesitate in recommending the SpiroChem team to others in need of expert synthetic chemistry guidance and support.

Nicholas Stock, Ph.D., Senior Vice President and Head of Chemistry, Actio Biosciences

SpiroChem Team were incredible to work with and fantastic at their job. They were full blown magicians when it came to chemical synthesis; it is so impressive to meet people with a strong intuition for chemical reactions and the ability to develop robust, economical procedures. The risk with outsourcing route scouting work is always that the contractors aren't invested in the outcome and therefore don't try too hard to make it work, but it was evident here that SpiroChem Team gave it their all, and they even worked beyond the scope of the project to deliver. Highly recommend!

Jessica Freyer, Partner, Rhapsody Venture Partners

Rajwinder Lehal, Chief Scientific Officer, Cellestia

It is with great joy that I am recommending SpiroChem based on the excellent job they did for us; Their high flexibility and reactivity to our fast-changing requests were outstanding. Furthermore, SpiroChem's excellent synthetic expertise enabled access to a key API, which we tested and proved to be the basis for the IP of a complete class of substances. Last but not least, I want to emphasize the outstanding and the fast delivery of the very detailed and precise final report with all the analytical documentation included.

Dr. Peter C. Sennhenn, CEO of transMedChem Consulting

We highly value our collaboration with SpiroChem, which enables us to address complex synthetic challenges across our pipeline programs. Their team demonstrates deep expertise in contemporary synthetic methodologies, and maintains rigorous attention to detail while aligning with our priorities for speed and efficiency. They additionally provide critical support to the Remix team by troubleshooting CRO-executed chemistry in China, contributing technical insight and actionable guidance through attendance at joint working group meetings.

Benoit Moreau, Head of Medicinal Chemistry, Remix Therapeutics

We greatly appreciated our collaboration with SpiroChem, whose partnership allowed us to efficiently tackle complex synthetic challenges across our research programs. Their team combines deep expertise in cutting-edge synthetic and medicinal chemistry with a pragmatic approach to speed, quality, and problem-solving. Beyond their direct scientific contributions, SpiroChem played a key coordinating role across our extended network of external CRO partners in China, India, and Ukraine. Their proactive management, technical oversight, and troubleshooting support have been instrumental in maintaining consistency, accelerating timelines, and ensuring scientific rigor throughout our global chemistry operations.

Chris Oalmann, Vice President Medicinal Chemistry, Superluminal Medicines

Odyssey Therapeutics and SpiroChem collaborated on the synthesis of complex molecules and chemical libraries. The SpiroChem team was highly engaged as we defined the scope and aims of the work. SpiroChem worked quickly to evaluate multiple chemistries in parallel. Together, we defined the most productive and impactful path forward, executing on state-of-the-art, challenging synthetic transformations, then quickly converting the results to library production.

Our collaboration proceeded smoothly as SpiroChem scientists were model collaborators who communicated promptly, provided very efficient logistics, and exhibited a true can-do spirit. It was a pleasure to work with the SpiroChem team and we look forward to future work together.

Natalie Dales, Chief of Research Operations and Portfolio Strategy, and Paul Gormisky, Senior Director of Chemistry, Odyssey Therapeutics

SpiroChem's expertise in synthetic chemistry, combined with their sense of urgency, make them an ideal partner for exploring new chemical space. Our critical collaboration on bicycloalkyl bioisosteres was published on ChemMedChem 2017 12 590. I have to highlight the ease of communication and the proactive role of SpiroChem, which we regularly experienced in our interactions. They are brilliant to work with, both for standard synthesis or more demanding customized building blocks and I would recommend their services to any company seeking pragmatic, cutting-edge solutions.

Dr. Yves P. Auberson, Executive Director, Global Discovery Chemistry, Novartis Institutes for BioMedical Research and President of EEMC

SpiroChem is a truly outstanding partner for the synthesis of customized building blocks, combining high technical expertise, creativity and a strong commitment with a very collaborative approach and a focus on delivery. Excellent communication, innovative ideas at the start of the project and proactive problem-solving by the SpiroChem team contribute to the success of projects. I have no hesitation in recommending SpiroChem.

Fredrik Cederbaum, Head of Fungicide Chemistry & Chemistry Operations, Syngenta

SpiroChem collaborated with ASCENZA in the synthesis of several complex and challenging compounds. Through the project, the SpiroChem team overcame all the challenges and presented solutions for all the problems encountered. The chemists are well prepared and very knowledgeable, which made some issues look easy to solve, when they weren't. We were impressed with the efficiency and fast delivery of all compounds and employment of state-of-the-art synthetic and purification methodologies. The communication was very smooth and assertive, with focus on providing the best results. All the discussions were very fruitful, and, at the end, we all learnt something. As a synthetic chemist, I couldn't be happier with this collaboration, and I highly recommend SpiroChem. Hopefully, we can work together soon.

Carlos Monteiro, Screening & Synthesis Coordinator, ASCENZA

It has been a pleasure working with the talented chemists at SpiroChem. Chemistry has proceeded efficiently even with challenging analogs. The team is very responsive to email and flexible to new analogs. Meetings are conducted efficiently and professionally.

It is great to work with a team that can identify potential issues prior to synthesis and troubleshoot solutions on difficult chemistry. I would recommend SpiroChem, especially if a highly skilled, driven, and professional chemistry team is desired.

David Witter, Ph.D., Vice President, Drug Discovery, SAILBio

Our collaboration with SpiroChem has enhanced our ability to investigate novel chemical space. The SpiroChem team and our team have built an outstanding partnership, working closely to resolve tough synthetic issues and quickly explore areas, which - without their expertise - would have been challenging. Their emphasis on communication, rapid delivery with uncompromised quality and troubleshooting solutions makes SpiroChem a highly recommended partner.

Stephanos Ioannidis, Vice President, Head of Chemistry, H3 Biomedicine

Thank you SpiroChem for your work, it was a truly exciting and fruitful collaboration. You did an outstanding job in an extremely short period of time. We really appreciated the regular reports of your progresses and the dynamic exchanges we had on these occasions, in a nice yet very professional atmosphere. Overall, we believe that our work with SpiroChem was a success and have significantly contributed to move forward with our project.

Christelle A. M. Robert, Prof., Head of the Chemical Ecology Group

I am writing to express my appreciation for the exceptional professionalism, technical expertise, and problem-solving abilities demonstrated by the team at SpiroChem. My experience collaborating with SpiroChem met and exceeded my expectations for what we considered a very challenging task.

From the very start of the partnership, their professionalism was on full display in every interaction. Their prompt responses, attention to detail, and commitment to delivering top-notch service were truly commendable. Their team's professionalism set the bar high and instilled a sense of confidence in their expertise in an area of chemistry where our organization lacked experience. They showcased a profound understanding of complex technical matters and effortlessly navigated through challenges with finesse. Their analytical prowess, coupled with their creativity in problem solving, led to the swift proposal of rational alternatives to circumvent synthetic complications.

It was a pleasure working with SpiroChem and I would recommend their suite of services to anyone seeking unparalleled excellence in the area of late-stage functionalization.

Ryan Stites, Principal Research Scientist

Our collaboration with SpiroChem has been extremely positive and productive. We had the pleasure of working with one of their skilled chemists, who, besides having a deep expertise in organic chemistry, demonstrated a high level of creativity to tackle challenging targets. Communication with the entire SpiroChem team was always clear and proactive, and the quality of work consistently exceeded expectations. SpiroChem has proven to be a reliable and highly capable partner, and we look forward to continuing our collaboration on future projects.

William Menzer, Medicinal Chemist

The SpiroChem team is an outstanding partner for NBE-Therapeutics for finding and optimizing complex synthesis routes for our linker-payloads. SpiroChem's team members' ingenuity, efficiency and proactive attitude was key in finding novel avenues for synthesizing highly complex and also highly cytotoxic small molecules. Due to the close interactions between our teams, it feels like SpiroChem's team is part of NBE.

Ulf Grawunder, COO & CDO of NBE-Therapeutics

SpiroChem did an excellent job executing on a highly synthetically challenging medchem program, delivering key molecules on an aggressive timeline. Moreover, their attention to detail in written communication was much appreciated. Overall, SpiroChem are first rate partners for medicinal chemistry services.

Corey Reeves, Senior Director, Head of Medicinal Chemistry

Throughout our project, SpiroChem was very efficient and productive. They provided quality support making it easy for us to expand our research into new areas. We are looking forward to the next opportunity to work with a team of highly skilled chemists.

Gerhard Frey, Ph.D., Vice President of Technology Development, BioAlta

Cybrexa has had SpiroChem support its research chemistry efforts, with particular focus on research projects requiring a high level of synthetic chemistry insight, rigor and experience. I have not only been impressed with the quality and timeliness of SpiroChem's work, but also with the "added value" their chemists have shown with creative and practical suggestions for moving the project forward. Cybrexa has now focused all of its "high cost" challenging synthesis work at SpiroChem.

Rob Maguire, Director of Chemistry, Cybrexa Therapeutics

SpiroChem has been a highly valuable partner on technically challenging discovery efforts requiring access to complex and novel chemical space. Their scientific rigor, creativity, and execution capabilities consistently enabled rapid progress on sophisticated drug discovery programs involving advanced medicinal chemistry and emerging therapeutic modalities. We were particularly impressed by the team's problem-solving mindset, collaborative approach, and ability to deliver innovative solutions with strong scientific relevance. SpiroChem combines deep technical expertise with a highly effective discovery mindset, making them an excellent partner for complex therapeutic innovation programs.