3D fragments are increasingly being considered as complementary to their 2D counterparts and as crucial components to improve pharmacophore coverage and solubility, leading to better starting points for lead generation. They are also considered as useful for identifying hits for challenging targets and unpredictable secondary sites.
At SpiroChem, we use our in-house knowledge and expertise to design novel sp3-rich fragments with high 3D diversity shape.
Hit Validation Phase
Hit Expansion Phase
From one SpiroChem fragment, you can get access to expanded analogs with a wide range of 3D shapes.