Many therapeutically relevant targets remain resistant to traditional small-molecule screening approaches. These “undruggable” targets require innovative strategies to uncover new, ligand-efficient starting points.
At SpiroChem, we have developed the Rescue Package — an integrated workflow that combines macrocycle screening, biophysical characterization, and crystal soaking validation. This powerful approach enables the identification and structural validation of hits where conventional methods often fail.
Step 1: Macrocycle Library
Our unique and diverse macrocycle library provides access to novel chemical space beyond traditional small molecules.
- 8,200 to 960 semi-peptidic compounds, ready for screening (10 mM in DMSO)
- Molecular weight < 900 Da
- Designed for high conformational flexibility and enhanced binding potential
Step 2: Biophysical Screening
We leverage state-of-the-art affinity-based screening techniques to detect even the weakest or most transient interactions.
- Quantification of binding affinity and kinetics
- Detection of weak interactions often missed in HTS campaigns
- Scalable and broadly applicable across diverse target classes
Step 3: Crystal SmartSoak® Validation
Our Crystal SmartSoak® platform provides structural confirmation and visualization of the identified hits.
- High-resolution crystallographic validation of binding modes
- Structural insights for rational lead optimization
- Enables structure-based drug design for challenging targets
Why Choose the Rescue Package?
By combining advanced chemistry, sensitive biophysics, and high-quality structural biology, the Rescue Package helps transform previously inaccessible targets into actionable opportunities for drug discovery.
💡 Interested in learning more?
Get in touch with our team to discuss how the Rescue Package can support your discovery programs.
