Covalent targeting plays a rising role in Medicinal Chemistry and Chemical Biology.
Targeted Covalent Inhibitors (TCIs) typically arise from structure-based design, starting from optimized reversible ligands which are then modified by attachment of an electrophilic covalent reactive (“warhead”) to address a proximal amino acid. More recently, fragment-based, tethering-based approaches and DNA-encoded libraries featuring electrophilic ligands appear as alternative strategies.
At SpiroChem, we are very active in TCIs discovery :
- Our computational chemistry team actively supports design of novel covalent fragments and inhibitors.
- Thanks to unparalleled synthetic skills and deep knowledge, SpiroChem chemists bring highly productive support for TCIs-related projects by giving access to uncharted chemical space.
We will be happy to support your projects.
For more information, please contact Laurence Jung at laurence.jung@spirochem.com
