SpiroChem AG:
Rosental area, WRO-1047-3
Mattenstrasse 22
4058 Basel, Switzerland

Tel: + 41 61 685 95 00
E-mail: contact@spirochem.com


Swiss Discovery Sciences

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Chemical Solutions

Medicinal Chemistry
It’s all about passion

We assist you all the way to make your projects successful

We provide full medchem programs from hit validation to identification of the preclinical candidate or support for a specific phase of your project such as:

  • Hit Validation
  • Lead Optimization
  • Properties Optimization
  • IP Evaluation
  • Hit/Fragment Expansion
  • SAR Elucidation
  • Back-up programs
  • Patent Filing
  • Hit-to-Lead
  • Bioisosteric replacement strategies
Access our knowledge

Synthetic chemistry is
never a limitation

Thanks to continuous in-house research to explore new chemical space and troubleshoot synthetic issues, we have cutting-edge expertise in design, bio-isosteric replacement and scaffold hopping. At SpiroChem, we prepare the molecule we should not the one we could.

Time is precious

Your success is our priority

Equipped with peformant devices such as TLC/MS, Bench Top NMR, high-throughput purification machines, we optimize and save time to make your project advance faster.

Through +14 000 references in our catalog and dedicated SpiroKits, we have a direct access to smart building blocks and turnkey solutions.

Crafting the world

One thing in common: Passion for chemistry

Typical FTE-based research contracts

  • 1-6 chemists (at least 50% PhD)
  • Duration : 3-12 months
  • Strong management (PhD involved in the lab)

Cutting-edge Technologies

  • Photochemistry
  • Flow chemistry
  • Electrochemistry
  • Parallel synthesis
  • Microwave-assisted synthesis

Specific Chemistry Skills

  • Spiro and bicycloalkane derivatives
  • Sp3 and sp2-sp3 hybrid scaffolds
  • Natural products
  • Nucleosides/Nucleotides
  • Macrocycles
  • Peptidomimetics
  • Polysaccharides
FTE (Full-Time Equivalent)

Success Story / MedChem

Who: Biotech

Where: Asia

Problem: Design, synthesis and optimization of novel bicyclo[x.y.z]alkane derivatives

SpiroChem assigned one chemist of FTE-based contact for 6 months:

4 series developed : 20 final molecules delivered (5 to 15 steps)

New methodology developed for the synthesis of bicyclo[x.y.z]-pyrazole derivatives by modification of key functionalities

Successful introduction of 10 new bicyclo[x.y.z]alkane derivatives for use as non-classical bioisosteres

Validation of bioisosteric switch concept

Generation of novel chemical space

3D design confirmed by X-Ray cristallography

Subnanomolar activity and excellent ADME profile achieved


Dr. Rajwinder Lehal, chief scientific officer, Cellestia Biotech AG.

SpiroChem has played an instrumental part in Cellestia’s drug discovery and development program, proving to be a reliable partner in delivering quality results in a timely manner. Within the framework of this collaboration, the team has spared no effort in meticulously executing the plan and actively participating in project meetings to contribute to the success of our medicinal chemistry efforts. SpiroChem’s innovative and effective work helped us save CHF 0,5 million on the drug development program. I thoroughly enjoyed interacting with SpiroChem’s team and CEO Dr. Thomas Fessard who always made himself personally available to discuss the progress of our projects. Without any reservations, I would highly recommend SpiroChem to anyone looking for customized, innovative chemistry from a highly invested, strikingly professional team.


Pablo German, Chief Technical Officer – Pheromite

SpiroChem services have been invaluable with lead optimization, starting with medicinal chemistry advice, following with compound synthesis, and finally reporting. We now have a more comprehensive understanding of the structure-activity relationship and a more solid foundation for our IP. The SpiroChem team are very efficient and deliver excellent quality on time, providing good value for money.

Medicinal Chemistry

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