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Discovery
Discovery
Process R&D
Process R&D
Fully integrated services
Fully integrated services
- Our expert partner network
- Consulting
Technology
Technology
News
News
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About

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COVID-19 Statement
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Newsletter

Oct 22, 2024

How Effective Route Scouting Saved...

Newsletter

Oct 22, 2024

Macrocycles modulating challenging targets

Newsletter

Sep 19, 2024

Medicinal chemistry competence powered by...

Expertise of the month, Newsletter

May 13, 2024

Expertise of the month: Synthetic...

Literature, Newsletter

Mar 16, 2024

SpiroChem’s Macrocycle Library delivers clinical...

Expertise of the month, Newsletter

Jan 30, 2024

Expertise of the month: Identification...

Expertise of the month, Newsletter

Jun 29, 2023

Photoredox catalysis and Electrochemistry enabling...

Expertise of the month, Newsletter

May 30, 2023

Expertise of the month: Strong...

Expertise of the month, Newsletter

Apr 28, 2023

Expertise of the month: Libraries...

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Discovery
Process R&D
Fully Integrated Services
Technology
Resources
Careers
About

Get in touch

contact@spirochem.com +41 61 685 9500 Follow us

Informations

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Impressum

https://tools.google.com/dlpage/gaoptout
https://allaboutcookies.org/

Stay Connected

Stay inspired with our newsletter subscription, keeping you informed on new concepts, products, solutions & more.

Medicinal Chemistry

Our Mission: Accelerate your project!

Typically : 1-6 chemists

Duration : 3-12+ months

Excellence in chemistry
Creative drug design
Solution and productivity driven
Uncompromised quality

Full MedChem programs or Support for a specific phase:

Hit Validation
Hit/Fragment Expansion
Hit-to-Lead

Lead Optimization
SAR Elucidation
Bioisosteric replacement strategies

Properties Optimization
Back-up programs
IP Evaluation
Patent Filing

Hit Validation
Hit/Fragment Expansion
Hit-to-Lead
Lead Optimization
SAR Elucidation

Bioisosteric replacement strategies
Properties Optimization
Back-up programs
IP Evaluation
Patent Filing

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MedChem Enabling Platforms

Our Mission: Explore new chemical space for you

Typically : 2-5 chemists

Duration : 3-12+ months

Opening of new exit vectors
Late-stage functionalization
Synthesis tractability
Unleashed design

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Fragment Libraries

Our Mission: Address unexplored chemical space and diversity

+700 molecules in stock
Unique design
High sp³ content
Conformationally restricted structures
Scale-up and straightforward analoging guaranteed

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DEL Scaffolds

Our Mission : Offer exclusive scaffolds

Bi- and tri-functionalized scaffolds
Uncharted chemical space
Unique dihedral angles covered
Orthogonal protecting groups
Vectors : COOH, CHO, Aryl halides, Nboc, Nfmoc, boronates

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Route Scouting

Our Mission: Design and implement de novo synthetic routes

Typically: 1-3 chemists

Duration: 3-6+ months

De novo design of synthetic routes to target molecules
Trouble-shooting
Development of efficient in-process controls
Stress test, robustness check
Technology transfer package

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SpiroKits

The must-have medicinal chemistry toolbox designed to:

Provide medchem turnkey solutions
Accelerate projects
Foster chemical space exploration
Support novelty

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Catalog

Our mission: Accelerate your R&D

+13 000 molecules
Innovative building blocks
Purity > 95%
Milligram to hundred gram scale
Short delivery time

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Consulting

Our mission: Share our knowledge

Literature analysis
Analysis of SAR results and proposals
Strategy proposals for ADME optimization
Retrosynthetic analysis
Route scouting proposals
Patent gap analysis
Support for patent filing

*hourly rate, daily rate or project-based fee

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Computational Chemistry

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