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pKa-tuned amines
SpiroKit 1: pKa-tuned amines

Why SpiroKit 1?

Strong basic centres (pKa > 10) are likely to be fully ionized at a physiological pH of 7.4 and are then unlikely to cross membranes by passive diffusion. Moreover, strong basic molecules are known to lead to hERG toxicity issue, high P-gp efflux and significant binding with α-acid glycoprotein in plasma.

To help you anticipate these issues and make you save time in your research programs, SpiroChem designed the pKa-tuned amines SpiroKit.

SpiroKit 1: pKa-tuned amines

Offered subsets

SPIROKIT 1a: Azetidine-like derivatives

A selection of 7 azetidine-like derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1a 7 100mg CHF 940 USD 1.119
250mg CHF 1.880 USD 2.109
500mg CHF 2.960 USD 3.319

A selection of 9 pyrrolidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1b 9 100mg CHF 670 USD 749
250mg CHF 1.270 USD 1.419
500mg CHF 1.990 USD 2.219

A selection of 12 piperidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1c 12 100mg CHF 740 USD 829
250mg CHF 1.480 USD 1.659
500mg CHF 2.360 USD 2.639

A selection of 6 advanced piperidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1d 6 100mg CHF 1.020 USD 1.139
250mg CHF 1.990 USD 2.229
500mg CHF 2.990 USD 3.339

A selection of 8 piperazine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1e 8 100mg CHF 1.150 USD 1.289
250mg CHF 2.190 USD 2.449
500mg CHF 3.500 USD 3.909

A selection of 4-amino-piperidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1f 9 100mg CHF 1.990 USD 2.219
250mg CHF 3.780 USD 4.229
500mg CHF 6.040 USD 6.749

A selection of 3-amino-piperidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1g 4 100mg CHF 840 USD 939
250mg CHF 1.600 USD 1.789
500mg CHF 2.560 USD 2.859

A selection of 3-amino-pyrrolidine derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1h 5 100mg CHF 940 USD 1.049
250mg CHF 1.790 USD 1.999
500mg CHF 2.860 USD 3.199

A selection of 6 bicyclic diamino derivatives with modulated pKa.

Catalog ID Compounds Amount (each) Price
SPK1j 6 100mg CHF 1.690 USD 1.889
250mg CHF 3.210 USD 3.589
500mg CHF 5.130 USD 5.739
SpiroKit 1: pKa-Tuned amines

Request an Order

To place an order please contact Laurence Jung, PhD: laurence.jung@spirochem.com, and indicate the SpiroKits of interest with the required quantities.

SpiroKits

Other SpiroKits

SpiroKit 2

sp2 to sp3
switch

SpiroKit 3

Constrained amino acids

SpiroKit 4

Azaspiro[3.3]heptane derivatives

SpiroKit 5

Bicyclic diamines

SpiroKit 6

Constrained amino alcohols

SpiroKit 7

Bicyclic amino ketones

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